Organotin compounds alter the physical organization of phosphatidylcholine membranes
نویسندگان
چکیده
منابع مشابه
The chemical toxic benzo[a]pyrene perturbs the physical organization of phosphatidylcholine membranes.
The interaction of the chemical carcinogen benzo[a]pyrene (BaP) with phosphatidylcholine membranes has been investigated by using various physical techniques. Differential scanning calorimetry showed that BaP, at concentrations as low as 2 mol% in mixtures with dimyristoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine, and distearoylphosphatidylcholine, abolished the pretransition a...
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Organotin compound that have at least one Sn-C bond have wide commercial applications as PVC stabilizer, antifouling agent in paint and as agrochemicals. The general formula for organotin compounds is R4SnX4 - n where R is normally alkyl or aryl groups and X=Cl-, OH-, CH3COO- . If n=3, the compound has the highest toxicity, for example Et3SnOAC has LD 50 4mg/Kg ( rats ) and this is the m...
متن کاملorganotin compounds and the environment
organotin compound that have at least one sn-c bond have wide commercial applications as pvc stabilizer, antifouling agent in paint and as agrochemicals. the general formula for organotin compounds is r4snx4 - n where r is normally alkyl or aryl groups and x=cl-, oh-, ch3coo- . if n=3, the compound has the highest toxicity, for example et3snoac has ld 50 4mg/kg ( rats ) and this is the most tox...
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15 صفحه اولRole of hydrophobic and hydrophilic interactions of organotin and organolead compounds with model lipid membranes.
The present study was conducted to clarify the mechanism of toxicity of organic compounds using lipid model membranes (liposomes and planar lipid membranes). The compounds studied were trialkyltin and trialkyllead chlorides, dialkyltin dichlorides and some inorganic forms of those metals. Two different (anionic and cationic) detergents were also used in the experiments to change the surface pro...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2001
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(00)00365-5